{Reference Type}: Case Reports
{Title}: β-Thalassemia Intermedia Caused by the β-Globin Gene 3' Untranslated Region: Another Case Report.
{Author}: Jiang F;Chen GL;Li J;Tang XW;Li DZ;
{Journal}: Hemoglobin
{Volume}: 46
{Issue}: 2
{Year}: Mar 2022
{Factor}: 0.822
{DOI}: 10.1080/03630269.2022.2086135
{Abstract}: The 3' untranslated region (3'UTR) is associated with mRNA stability because of its involvement in 3' end processing, polyadenylation, and mRNA capping. Mutations located in this area can cause a phenotype compatible with β+-thalassemia (β+-thal). We report a Chinese subject with β-thal intermedia (β-TI) who developed transfusion-dependent anemia. Molecular studies revealed that the patient was a compound heterozygote for two β-thal alleles: codons 41/42 (-TTCT) (HBB: c.126_129delCTTT) and term codon +32 (A>C) (HBB: c.*32A>C).