{Reference Type}: Case Reports
{Title}: GM-CSF antibodies in artificial stone associated silicoproteinosis: A case report and literature review.
{Author}: Khan SNS;Stirling RG;Mclean CA;Russell PA;Hoy RF;
{Journal}: Respirol Case Rep
{Volume}: 10
{Issue}: 9
{Year}: Sep 2022
暂无{DOI}: 10.1002/rcr2.1021
{Abstract}: Pulmonary alveolar proteinosis (PAP) is a rare lung disease where there is accumulation of surfactant in the alveoli. It can be classified based on the underlying aetiology into three categories: primary, secondary and congenital. Autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF-Ab) are a key diagnostic feature of autoimmune PAP. High intensity occupational exposure and inhalation of toxic particles such as silica can cause a form of secondary PAP called acute silicoproteinosis. We describe a 26-year-old stone benchtop fabricator with silicoproteinosis following daily exposure to high levels of silica who had elevated serum GM-CSF-Ab. We discuss the role of GM-CSF-Ab in cases of PAP with occupational inhalational exposure and the challenges in its interpretation.