{Reference Type}: Case Reports
{Title}: Peritonitis after exposure to biocontrol-agent fumes containing Talaromyces flavus: a case report in peritoneal dialysis patient.
{Author}: Sookto P;Kanjanabuch T;Chamroensakchai T;Thongbor N;Eiam-Ong S;Sookto P;Kanjanabuch T;Chamroensakchai T;Thongbor N;Eiam-Ong S;
{Journal}: BMC Nephrol
{Volume}: 23
{Issue}: 1
{Year}: Aug 2022 9
{Factor}: 2.585
{DOI}: 10.1186/s12882-022-02898-1
{Abstract}: <B>BACKGROUND: </B>The first case of Taralomyces flavus infection in human and peritoneal dialysis (PD) patient after exposure to biocontrol agent fumes is reported here.<BR><B>METHODS: </B>A 77-year-old Thai female farmer with kidney failure presented with peritonitis and PD catheter obstruction from fungal biofilms. The potential root cause of infection was associated with exposure to biocontrol-agent fumes containing pathogen during agricultural work in her garden. This source of infection has not been mentioned previously. Showering and changing clothes right after outdoor activity with a high density of fungal matters or dust should be added to the routine aseptic technique before performing PD bag exchange to prevent the system contamination. Although the patient received early treatment with liposomal amphotericin B, itraconazole, and catheter removal, according to the ISPD Guideline 2016 and the Global Guideline 2021, the outcome was unfavorable. Antifungal susceptibility testing later revealed that the pathogen was only susceptible to voriconazole. Thus, antifungal susceptibility should be tested if the patient fails or slowly responds to the primary antifungal regimen.<BR><B>CONCLUSIONS: </B>T. flavus peritonitis is reported here after exposure to biocontrol-agent fumes containing the pathogen. This work also alerts and reiterates nephrology peers to be aware of this overlooked source of peritonitis, the exposure to dusty environments, specifically containing biocontrol-agent fumes.