{Reference Type}: Journal Article
{Title}: Effect of Vaccination against Leptospira on Shelter Asymptomatic Dogs Following a Long-Term Study.
{Author}: Sant'Anna da Costa R;Di Azevedo MIN;Dos Santos Baptista Borges AL;Aymée L;Martins G;Lilenbaum W;
{Journal}: Animals (Basel)
{Volume}: 12
{Issue}: 14
{Year}: Jul 2022 12
{Factor}: 3.231
{DOI}: 10.3390/ani12141788
{Abstract}: (1) Background: Vaccination of dogs against leptospirosis is of paramount importance, as they ideally must provide not only long-term protection, but also against the renal carrier state of leptospires. This study assessed the post-vaccine humoral response against Leptospira in naturally exposed dogs and effects on renal carrier status. (2) Methods: A total of 118 dogs were studied for 365 days, separated into Group A (vaccinated, n = 94) and Group B (non-vaccinated, n = 24). Group A was subdivided into three groups: A1 with 32 dogs immunized with the vaccine #1; A2 by 32 dogs with #2; and A3 30 dogs with #3. Serology (MAT and IgG-ELISA) and urinary PCR were conducted. (3) Results: Seroreactivity increased at D15 post-vaccination and, regardless of vaccine brand, remained high up to D180, with antibody switch to IgG after D30. A total of 46.8% of animals from Group A were PCR-positive at least once, in contrast to 75% in Group B, regardless of vaccine brand (p < 0.05; OR: 0.3). (4) Conclusions: All commercial vaccines succeeded at eliciting a long-term IgG-based response and were partially effective at protecting against kidney infection.