{Reference Type}: Journal Article
{Title}: Chromatographic analysis of dithiocarbamate residues and their metabolites in foods employed in dietary exposure studies-a review.
{Author}: Chung SWC;Wong WWK;
{Journal}: Food Addit Contam Part A Chem Anal Control Expo Risk Assess
{Volume}: 39
{Issue}: 10
{Year}: Oct 2022
{Factor}: 3.549
{DOI}: 10.1080/19440049.2022.2103186
{Abstract}: Dithiocarbamates (DTCs) belong to a group of compounds used as fungicides in food production and can be divided into three major groups. Since DTCs easily oxidise and hydrolyse in alkaline and acidic medium respectively, precautions have to be implemented during preparation/homogenisation and extraction of samples. As such, test samples are commonly prepared individually by cutting into small pieces just before the digestion of DTCs with a hot acid to give carbon disulphide (CS2) and the results are expressed as CS2 without any differentiation of individual DTCs. However, individual DTCs have different toxicological potencies whilst their metabolites are more toxic than the parent compound. Apart from the hot digestion method, chromatographic separation of three major groups of DTCs has been developed by a number of different researchers. This review provides a comprehensive examination of sample preparation, extraction, clean-up and chromatographic methods for the determination of individual DTCs and their more toxic metabolites in foodstuffs. Moreover, this review also studies on how dietary exposure of DTCs can be efficiently and effectively estimated using different methods of analysis.