{Reference Type}: Journal Article
{Title}: Host stimulator of interferon genes is essential for the efficacy of anti-programmed cell death protein 1 inhibitors in non-small cell lung cancer.
{Author}: Zhou L;Xu Q;Huang L;Zhan P;Jin J;Ye M;Liu H;Zhang F;Wang Z;Liu J;Chen C;Han H;Zhang Q;Zhu S;Ren J;Lv T;Song Y;
{Journal}: Immunology
{Volume}: 167
{Issue}: 4
{Year}: 12 2022
{Factor}: 7.215
{DOI}: 10.1111/imm.13549
{Abstract}: The stimulator of interferon genes (STING) pathway is important for anticancer immune responses. However, the relative contributions of host and tumour STING in anti-programmed cell death protein 1 (anti-PD-1) inhibitor responses in non-small cell lung cancer (NSCLC) are unknown. STING expression in tumour and blood was associated with anti-PD-1 therapy in NSCLC patients; Moreover, loss of PD-1 inhibitor therapeutic potency was demonstrated in STING KO (knock out) splenocytes and STING KO mice. STING knock-down in tumour cells had no effect. STING on CD8+ T cells and host cells, not tumour cells, correlated with clinical effect of anti-PD-1 therapy in NSCLC patients. Finally, adoptive transfer of CD8+ T cells restored PD-1 inhibitor anticancer effects. STING in host cells but not in tumour cells mediates anti-PD-1 inhibitor responses in cancer immunotherapy and could be used to select advantageous NSCLC patients from immunotherapy.