{Reference Type}: Journal Article {Title}: Commentary: statistical analysis of 2 × 2 tables in biomarker studies 3) design, interpretation and guidelines. {Author}: Lovell DP; {Journal}: Biomarkers {Volume}: 27 {Issue}: 6 {Year}: Sep 2022 {Factor}: 2.663 {DOI}: 10.1080/1354750X.2022.2096927 {Abstract}: This article discusses issues associated with the design and interpretation of biomarker studies, points to various guidelines and lists points to look out for in assessing studies.