{Reference Type}: English Abstract
{Title}: [Lung transplantation for pulmonary alveolar proteinosis: a case report and literature review].
{Author}: Wang YB;Li FK;Ding ZD;Zhao K;Fang ZM;Feng M;Chang SY;Jin F;Huang MJ;Zhao GF;Wang YB;Li FK;Ding ZD;Zhao K;Fang ZM;Feng M;Chang SY;Jin F;Huang MJ;Zhao GF;
{Journal}: Zhonghua Jie He He Hu Xi Za Zhi
{Volume}: 45
{Issue}: 7
{Year}: Jul 2022 12
暂无{DOI}: 10.3760/cma.j.cn112147-20220302-00165
{Abstract}: Objective: To observe the efficacy of lung transplantation for pulmonary alveolar proteinosis (PAP) patients and to improve the understanding of the therapy. Methods: The clinical data of a patient with autoimmune PAP treated with sequential homogenous bilateral lung transplantation were described and the literatures were reviewed. Results: This 55-year-old female patient was diagnosed with autoimmune PAP and had been treated with whole lung lavage for 19 times, but only achieved short-term symptomatic relief after each operation. Inhalation of granulocyte macrophage colony stimulating factor occurred allergic reactions. Lung transplantation was performed on February 15, 2022, and a significant improvement in oxygenation and clinical symptoms were observed. The patient remained stable during follow-up. Conclusion: Treatment with lung transplantation is safe and effective for end-stage patients with PAP in the early phase, but the long-term effect remains to be observed.<BR>目的： 探讨肺移植治疗终末期肺泡蛋白沉积症的疗效。 方法： 患者女，55岁，因“胸闷、气喘伴咳嗽6年，加重1年”入院，经反复多次全肺灌洗治疗，效果欠佳，遂行同种异体序贯式双肺移植治疗，观察其临床资料并进行相关文献复习。以“肺移植”和“肺泡蛋白沉积症”为检索词检索中国知网及万方医学网中文文献数据库，以“lung transplantation”及“pulmonary alveolar proteinosis”为检索词检索PubMed数据库，检索时间截止到2022年2月。 结果： 该患者既往行全肺灌洗19次，前期效果尚可，后期症状进行性加重，粒细胞-巨噬细胞集落刺激因子雾化吸入治疗后，出现过敏反应，胸部CT提示肺部病变逐渐加重。2022年2月15日行肺移植术，PaO2从47 mmHg（1 mmHg=0.133 kPa）上升到85 mmHg，可脱离吸氧活动，2022年3月2日出院，随访病情稳定。文献检索获得相关英文文献13篇，其中论著2篇，病例报告11篇；肺移植后继发肺泡蛋白沉积症9篇；肺移植治疗肺泡蛋白沉积症4篇，报道了3个病例；国内未见肺移植治疗肺泡蛋白沉积症的报道。 结论： 肺移植治疗终末期肺泡蛋白沉积症，早期安全有效，长期效果有待进一步观察。.