{Reference Type}: Journal Article
{Title}: Is anemia frequently recognized in gastroschisis compared to omphalocele? A multicenter retrospective study in southern Japan.
{Author}: Sugita K;Muto M;Oshiro K;Kuda M;Kinjyo T;Masuya R;Machigashira S;Kawano T;Nakame K;Torikai M;Ibara S;Kaji T;Ieiri S;Sugita K;Muto M;Oshiro K;Kuda M;Kinjyo T;Masuya R;Machigashira S;Kawano T;Nakame K;Torikai M;Ibara S;Kaji T;Ieiri S;
{Journal}: Pediatr Surg Int
{Volume}: 38
{Issue}: 9
{Year}: Sep 2022
{Factor}: 2.003
{DOI}: 10.1007/s00383-022-05150-x
{Abstract}: <B>OBJECTIVE: </B>We compared cases of anemia in gastroschisis versus omphalocele and investigated this clinical question.<BR><B>METHODS: </B>A multicenter study of five pediatric surgery departments in southern Japan was planned. Sixty patients were collected between 2011 and 2020, with 33 (gastroschisis: n = 19, omphalocele: n = 14) who met the selection criteria ultimately being enrolled. Anemia was evaluated before discharge and at the first outpatient visit.<BR><B>RESULTS: </B>Despite gastroschisis cases showed more frequent iron administration during hospitalization than omphalocele (p = 0.015), gastroschisis cases tended to show lower hemoglobin values at the first outpatient visit than omphalocele cases (gastroschisis: 9.9 g/dL, omphalocele: 11.2 g/dL). Gastroschisis and the gestational age at birth were significant independent predictors of anemia at the first outpatient visit, (gastroschisis: adjusted odds ratio [OR] 19.00, p = 0.036; gestational age at birth: adjusted OR 0.341, p = 0.028). A subgroup analysis for gastroschisis showed that the ratio of anemia in the 35-36 weeks group (8/10, 80.0%) and the > 37 weeks group (6/6, 100%) was more than in the < 34 weeks group (0/3, 0.0%).<BR><B>CONCLUSIONS: </B>Gastroschisis may carry an increased risk of developing anemia compared with omphalocele due to the difference of direct intestinal exposure of amnion fluid in utero.