{Reference Type}: Journal Article
{Title}: Monoclonal gammopathy of renal significance presenting with cryoglobulinaemia type I associated severe thrombotic microangiopathy.
{Author}: Hesius E;Bunthof K;Steenbergen E;de Kort E;Klein I;Wetzels J;
{Journal}: Clin Kidney J
{Volume}: 15
{Issue}: 7
{Year}: Jul 2022
{Factor}: 5.86
{DOI}: 10.1093/ckj/sfac078
{Abstract}: We report a 53-year-old man who presented with acute renal failure. His medical history revealed a spondyloarthropathy, for which secukinumab was started recently, and a monoclonal gammopathy of unknown significance. Kidney function deteriorated despite the withdrawal of secukinumab and dialysis was started. In the serum, type 1 cryoglobulins were present and a kidney biopsy showed ischaemic glomeruli, with thrombosis of the larger interlobular arteries. Other causes of thrombotic microangiopathy were excluded. Bone marrow immunophenotyping showed 1% monoclonal plasma cells. A diagnosis of monoclonal gammopathy of renal significance was made. Haematological treatment resulted in haematological and renal response.