{Reference Type}: Case Reports
{Title}: Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders - Outcome After Hematopoietic Stem Cell Transplantation.
{Author}: Baumann U;Schulte JH;Groß JP;Beier R;Ludwig M;Wahn V;Hofmann J;Maecker-Kolhoff B;Sauer M;Kaiser-Labusch P;Karimian N;Blume-Peytavi U;Ghoreschi F;Ott H;Perelygina L;Klemann C;Blankenstein O;von Bernuth H;Krüger R;
{Journal}: Front Immunol
{Volume}: 13
{Issue}: 0
{Year}: 2022
{Factor}: 8.786
{DOI}: 10.3389/fimmu.2022.886540
{Abstract}: We report two patients with DNA repair disorders (Artemis deficiency, Ataxia telangiectasia) with destructive skin granulomas, presumably triggered by live-attenuated rubella vaccinations. Both patients showed reduced naïve T cells. Rapid resolution of skin lesions was observed following hematopoietic stem cell transplantation. However, the patient with AT died due to complications of severe hepatic veno-occlusive disease 6 month after HSCT. Dried blood spots obtained after birth were available from this patient and showed absent T-cell receptor excision circles (TRECs). Therefore, newborn screening may help to prevent patients with moderate T-cell deficiency from receiving live-attenuated rubella vaccine potentially causing granulomas.