{Reference Type}: Journal Article
{Title}: Dectin-2 promotes house dust mite-skewed Th2 response through the activation of cDC2s.
{Author}: Qu Y;Ma X;Deng J;Shang Y;Shang K;Wang X;Guo Z;Bai C;
{Journal}: Cell Immunol
{Volume}: 378
{Issue}: 0
{Year}: 08 2022
{Factor}: 4.178
{DOI}: 10.1016/j.cellimm.2022.104558
{Abstract}: The role of Dectin-2 (gene symbol, Clec4n) in house dust mite (HDM) induced Th2 immune response and the exact mechanism remains controversial. In this study, we illustrated that, Clec4n-/- mice had decreased Th2 immune response following HDM challenge, which may ascribe to dramatically reduced type 2 conventional dendritic cells (cDC2s) in lung of Clec4n-/- mice, as cDC2s from lung of Clec4n-/- mice after challenging had less ability to induce Th2 response with decreased production of IL-4/IL-13. Further in vitro experiments showed the activation of Clec4n-/--BMDCs significantly decreased after HDM stimulation accompanied with decreased activation of Syk-NF-κB and Syk-JNK signal pathway. Importantly, Dectin-2 expression in PBMCs from asthmatic patients was significantly higher than that in healthy controls. Taken together, these results demonstrated that Dectin-2 could promote cDC2s activation in lung, which polarizes Th2 immune response outlining a novel mechanism of asthma development.