{Reference Type}: Journal Article
{Title}: Identifying selection signatures and runs of homozygosity for spine curvature in Chinese indigenous pigs.
{Author}: Jiayuan M;Yujie L;Kuirong C;Siran Z;Wenjing Q;Lingli F;Xiaoxiao L;Liang L;Ganqiu L;Jing L;Jiayuan M;Yujie L;Kuirong C;Siran Z;Wenjing Q;Lingli F;Xiaoxiao L;Liang L;Ganqiu L;Jing L;
{Journal}: Anim Genet
{Volume}: 53
{Issue}: 4
{Year}: Aug 2022
{Factor}: 2.884
{DOI}: 10.1111/age.13224
{Abstract}: In China there are approximately 100 pig breeds, which show great diversity in their appearance. However, information on genome selection signatures, such as spine curvature, is scarce. Therefore, we used the fixation index (FST ) and cross-population extended haplotype homozygosity (XPEHH) methods to explore the genome selection signatures of spine curvature in six breeds of Chinese indigenous pig. We identified 396 and 389 single nucleotide polymorphisms using the FST and XPEHH methods, respectively. We detected 19 selection signatures and 28 genes located in the selected regions. Five candidate genes (MAP3K7, CUX1, GRIN2B, ALPL and MACF1) were identified in the selection signatures. Additionally, 719 high-frequency runs of homozygosity regions, 17 unique runs of homozygosity regions, 78 genes and 27 pathways were identified in the runs of homozygosity analysis. The TGF-beta signaling pathway and eight genes related to the spine formation, spine defects and intervertebral disk degeneration were identified, comprising ACVR1, FMOD, ITGA4, MAPK8, PDGF, RPL3, SULF1 and UBE2D1. In summary, we identified 13 candidate genes related to spine curvature in Chinese indigenous pigs.