{Reference Type}: English Abstract
{Title}: [The prognostic value of preoperative neutrophil-to-lymphocyte ratio in patients with non-metastatic renal cell carcinoma].
{Author}: Chaker K;Ouanes Y;Dali KM;Bibi M;Messaoudi Y;Mosbehi B;Abid K;Sellami A;Ben Rhouma S;Nouira Y;Chaker K;Ouanes Y;Dali KM;Bibi M;Messaoudi Y;Mosbehi B;Abid K;Sellami A;Ben Rhouma S;Nouira Y;Chaker K;Ouanes Y;Dali KM;Bibi M;Messaoudi Y;Mosbehi B;Abid K;Sellami A;Ben Rhouma S;Nouira Y;
{Journal}: Prog Urol
{Volume}: 32
{Issue}: 8
{Year}: Jul 2022
{Factor}: 1.09
{DOI}: 10.1016/j.purol.2022.03.007
{Abstract}: BACKGROUND: The aim of this study was to investigate the prognostic significance of the preoperative neutrophil-to-lymphocyte ratio in non-metastatic renal cell carcinoma.
METHODS: We retrospectively analyzed the records of patients with non-metastatic renal cell carcinoma who were operated between 2004 and 2020 at our institution. The Kaplan-Meier method was utilized to graphically display survivor functions. Univariate and multivariate Cox's proportional hazards regression models were utilized to analyze the association between neutrophil-to-lymphocyte ratio and oncological outcomes.
RESULTS: We included 202 patients. Patients with higher neutrophil-to-lymphocyte ratio had larger tumors (P=0.03), higher ASA score (P=0.014), clinical symptoms (P=0.04), sarcomatoid differentiation (P=0.03) and tumor necrosis (P=0.02). The rates of recurrence-free survival and metastasis-free survival were significantly lower in patients with a high neutrophil-to-lymphocyte ratio than in those with a low ratio (P=0.017; P=0.036 respectively). Multivariate analysis identified the neutrophil-lymphocyte ratio as an independent predictor of recurrence-free and metastasis-free survival (P=0.021; P=0.001 respectively).
CONCLUSIONS: A higher neutrophil-to-lymphocyte ratio has been associated with a symptomatic renal cancer with a significant prognostic factor for both recurrence-free and metastasis-free survival.
METHODS: 3.