{Reference Type}: Journal Article
{Title}: Radiation-induced Brain Calcification Leads to L-dopa-resistant Parkinsonism and Cerebellar Ataxia.
{Author}: Shimada T;Kamo R;Daida K;Nishioka K;Hattori N;Tsunemi T;
{Journal}: Intern Med
{Volume}: 61
{Issue}: 24
{Year}: Dec 2022 15
{Factor}: 1.282
{DOI}: 10.2169/internalmedicine.8400-21
{Abstract}: We experienced a young patient who presented with progressive parkinsonism and cerebellar ataxia. Brain magnetic resonance imaging revealed progressive brain calcification, expanding from the bilateral basal ganglia to the central pons, caused by a delayed reaction to the radiation therapy that she had received to treat craniopharyngioma 14 years earlier. Heterogeneous clinical symptoms due to radiation-induced brain calcification have been described, but parkinsonism has never been reported. While dopamine transporter-single photon emission computed tomography revealed only slight damage to the dopaminergic striatal pathway, the extension of calcification to the periventricular white matter was likely responsible for her parkinsonism.