{Reference Type}: Case Reports
{Title}: Cyclic Fevers in Adult Diagnosed As Hyperimmunoglobulin D Syndrome.
{Author}: Reji M;Thapa R;
{Journal}: Cureus
{Volume}: 14
{Issue}: 4
{Year}: Apr 2022
暂无{DOI}: 10.7759/cureus.23878
{Abstract}: Hyper immunoglobulin D Syndrome (HIDS) is a rare autosomal recessive disease often presents during infancy. The disease is caused by an abnormal gene that codes for mevalonate kinase (MVK). This results in recurrent fever episodes and gastrointestinal discomfort (including diarrhea, joint pain, and oral sores). High fever is the most common symptom, occurring every few weeks to months. Patients may also have other findings, including lymphadenopathy and arthralgia. In this report, we discuss a rare diagnosis of HIDS is an adult and discuss our case in the context of existing literature. Given the nonspecific symptoms and the fact that it is often diagnosed in childhood, HIDS can be a challenging but essential diagnosis in adults with persistent, cyclical fevers.