{Reference Type}: Journal Article
{Title}: Investigation of the association between lens autofluorescence ratio and diabetes: a cross-sectional study.
{Author}: Yao J;Li W;Liu Y;Wu T;Wang D;Arezina R;Sun Z;Qiu S;Yao J;Li W;Liu Y;Wu T;Wang D;Arezina R;Sun Z;Qiu S;
{Journal}: Photodiagnosis Photodyn Ther
{Volume}: 38
{Issue}: 0
{Year}: Jun 2022
{Factor}: 3.577
{DOI}: 10.1016/j.pdpdt.2022.102888
{Abstract}: OBJECTIVE: Lens autofluorescence ratio (LFR) is a novel approach to detect advanced glycation end products in a time-saving and non-invasive manner. However, its associations with glycemia and diabetes remain unclear. We conducted this study to address this issue in Chinese adults.
METHODS: We enrolled a total of 4,705 participants aged 20-70 years in China between May 2020 and January 2021 in a cross-sectional study. LFR was determined by biomicroscopy (ClearPath DS-120). Diabetes was ascertained by oral glucose tolerance test, self-reported history, and/or antidiabetic medication use. Correlation and logistic regression analyses were performed.
RESULTS: LFR was higher in participants with diabetes than those without (23.27 ± 6.51 vs. 19.45 ± 5.08, p < 0.001). LFR correlated with fasting plasma glucose and hemoglobin A1c in the overall and diabetes-stratified populations. The odds of diabetes was increased by 6% per one percent higher of LFR after multivariable-adjustment (odds ratio (OR) 1.06, 95% CI 1.04-1.08, p < 0.001). Participants in the highest quartile of LFR had higher odds of diabetes compared with those in the lowest quartile (OR 1.83, 95% CI 1.33-2.52, p < 0.001). Mediation analysis showed that, insulin resistance, as assessed by triglyceride-glucose index, may underline the relationship between high LFR and increased odds of diabetes.
CONCLUSIONS: LFR, a non-invasive indirect measure of advanced glycation end products, appears to be associated with glycemia and the risk of developing diabetes in Chinese adults.