{Reference Type}: Journal Article
{Title}: Heat shock proteins and the calcineurin-crz1 signaling regulate stress responses in fungi.
{Author}: Roy A;Tamuli R;Roy A;Tamuli R;
{Journal}: Arch Microbiol
{Volume}: 204
{Issue}: 5
{Year}: Apr 2022 4
{Factor}: 2.667
{DOI}: 10.1007/s00203-022-02833-w
{Abstract}: The heat shock proteins (Hsps) act as a molecular chaperone to stabilize client proteins involved in various cell functions in fungi. Hsps are classified into different families such as HSP90, HSP70, HSP60, HSP40, and small HSPs (sHsps). Hsp90, a well-studied member of the Hsp family proteins, plays a role in growth, cell survival, and pathogenicity in fungi. Hsp70 and sHsps are involved in the development, tolerance to stress conditions, and drug resistance in fungi. Hsp60 is a mitochondrial chaperone, and Hsp40 regulates fungal ATPase machinery. In this review, we describe the cell functions, regulation, and the molecular link of the Hsps with the calcineurin-crz1 calcium signaling pathway for their role in cell survival, growth, virulence, and drug resistance in fungi and related organisms.