{Reference Type}: Historical Article
{Title}: Metastatic cancer along ancient Silk Road: A possible case from Xinjiang (China).
{Author}: He L;Gibbon VE;Xiao X;Wang B;Li H;
{Journal}: Int J Paleopathol
{Volume}: 37
{Issue}: 0
{Year}: 06 2022
{Factor}: 1.448
{DOI}: 10.1016/j.ijpp.2022.03.001
{Abstract}: Palaeopathological evidence of cancer, especially metastatic cancer, is rare in China. This paper describes and diagnoses a cranium with multiple lytic lesions recovered from the Sampula cemetery in Xinjiang, attempting to diagnose the type of disease that could have caused the pathological lesions observed.<BR>A cranium from an adult male (#00106) was recovered from the Sampula cemetery (dated to 55 BCE to 335 CE) located in the Luopu County, the Hotan River oasis on the southern edge of the Tarim Basin in southern Xinjiang.<BR>The cranium was assessed macroscopically and radiographically (CT).<BR>Multiple osteolytic lesions with irregular and "moth-eaten" margins were detected in cranium #00106. CT scans revealed the development of the lesions began at the diploe and identified a "button sequestrum".<BR>Based on lesion characteristics, metastatic carcinoma was likely the cause of lesions found in cranium #00106.<BR>This case has expanded our knowledge of the malignant neoplasms of ancient populations in northwest China and discusses the possible risk factors in the occurrence of cancer in the Sampula site, as well as the possible impacts of skeletal metastases on the individual.<BR>The distribution of osteolytic lesions over the complete skeleton cannot be observed because of the unavailability of postcranial bone.<BR>With the increasing number of reports describing diseases in ancient China, the patterns of diseases occurrence and development can be further explored from spatial and temporal perspectives.