{Reference Type}: Journal Article
{Title}: Topical Therapeutic Options in Corneal Neuropathic Pain.
{Author}: Nortey J;Smith D;Seitzman GD;Gonzales JA;
{Journal}: Front Pharmacol
{Volume}: 12
{Issue}: 0
{Year}: 2021
{Factor}: 5.988
{DOI}: 10.3389/fphar.2021.769909
{Abstract}: Purpose of Review: Corneal neuropathic pain can be difficult to treat, particularly due to its lack of response to standard dry eye therapies. We describe a variety of topical therapeutic options that are available to treat corneal neuropathic pain with a significant or primary peripheral component. We also describe possible mechanisms of action for such topical therapies. Recent Findings: Topical corticosteroids and blood-derived tear preparations can be helpful. Newer therapies, including topical lacosamide and low-dose naltrexone are emerging therapeutic options that may also be considered. Summary: Corneal neuropathic pain with a significant peripheral component may be managed with a variety of topical therapeutic options.