{Reference Type}: Journal Article
{Title}: The association of breastfeeding and other factors on respiratory virus positivity and severity in hospitalized children.
{Author}: Ferreira LH;Silva BGD;Giamberardino HI;Pacheco AP;Pereira LA;Genelhoud G;Petterle RR;Raboni SM;Ferreira LH;Silva BGD;Giamberardino HI;Pacheco AP;Pereira LA;Genelhoud G;Petterle RR;Raboni SM;
{Journal}: Microbiol Immunol
{Volume}: 66
{Issue}: 5
{Year}: May 2022
{Factor}: 2.962
{DOI}: 10.1111/1348-0421.12969
{Abstract}: Acute respiratory infections (ARIs) are the most prevalent diseases in children under 5 years old, and viruses are the leading cause. ARIs arise due to numerous factors, including age, contact with siblings or other children in daycare centers, and environmental pollution. Breastfeeding reportedly confers protection against ARIs through bioactive components related to mucous epithelial immunity. This study aimed to evaluate the frequency and severity of viral ARIs in hospitalized children, together with the status and duration of exclusive breastfeeding (EBF) and other associated factors. It comprised an epidemiological surveillance study to investigate respiratory viruses in hospitalized children, in which demographic and clinical data were collected. Overall, 279 patients were included, 190 (68%) had positive viral results, and 132 (47%) were exclusively breastfed. In an adjusted analysis, it was observed that older children, the parents' educational level, and the presence of chronic disease were significantly related to EBF for more than 6 months. No significant differences were observed in viral positivity and disease severity concerning EBF. Whereas the EBF status was associated with a positive rate of virus detection, the significance did not remain after adjustment, and it was not considered a protective factor against ARIs. On the other hand, young age and exposure to tobacco were confirmed as risk factors of frequency and severity, respectively. Such confounding factors can impact the analysis and should be considered in future studies.