{Reference Type}: Journal Article {Title}: High Value-Added Application of Two Renewable Sources as Healthy Food: The Nutritional Properties, Chemical Compositions, Antioxidant, and Antiinflammatory Activities of the Stalks of Rheum officinale Baill. and Rheum tanguticum Maxim. ex Regel. {Author}: Dai LX;Miao X;Yang XR;Zuo LP;Lan ZH;Li B;Shang XF;Yan FY;Guo X;Wang Y;Zhang JY;Dai LX;Miao X;Yang XR;Zuo LP;Lan ZH;Li B;Shang XF;Yan FY;Guo X;Wang Y;Zhang JY; {Journal}: Front Nutr {Volume}: 8 {Issue}: 0 {Year}: 2021 {Factor}: 6.59 {DOI}: 10.3389/fnut.2021.770264 {Abstract}: Rhubarb plants (Rheum officinale and R. tanguticum) have edible stalks. In this work, we aimed to compare the nutritional properties, chemical compositions, and bioactivities of R. officinale (SRO) and R. tanguticum (SRT) stalks and to analyze the composition-function relationship. Results showed that the two stalks were good sources of fiber, as well as minerals. They contained abundant essential amino acids and essential fatty acids to regulate the immunity and prevent some chronic diseases; the contents of polyunsaturated fatty acids were 2,244.32 mg/100 g and 2,844.69 mg/100 g, respectively. The antioxidant activity were also proved. Metabolomics showed that SRO and SRT contained abundant phenolic acids. Due to the higher concentrations of flavones, SRT has better antiinflammatory activities than SRO by inhibiting NF-κB signaling pathway. Rhubarb stalks exhibited good safety in acute toxicity and cytotoxicity tests. This work indicated that the two stalks have nutritional value, safety, and bioactivities, and could be used as sources of nutritional ingredients for regulating the immunity of body in food industry.