{Reference Type}: Journal Article
{Title}: A virus like particle approach to study the Chikungunya virus envelope protein mutations.
{Author}: Mathew AM;Anukumar B;
{Journal}: Virus Genes
{Volume}: 58
{Issue}: 2
{Year}: Apr 2022
{Factor}: 2.198
{DOI}: 10.1007/s11262-022-01885-w
{Abstract}: Virus like particles (VLPs) are used as a tool to study the mutations in the structural genes that influence the virus assembly and entry process. We observed that Chikungunya VLP with the E1:V291I mutation produced more fluorescence-positive cells in Vero cells than the other mutant VLPs (E1:A226V, D284E, and E2:V264A) and wild-type VLP tested in this study. According to the findings, the V291I mutation may aid the virus's ability to enter the cells more efficiently than wild-type VLPs. The study concludes that VLP is a useful model for studying the virus entry process in cells.