{Reference Type}: Journal Article
{Title}: Not-so-minimal for minimally invasive surgery.
{Author}: Ramesh A;Ramanjulu R;Shanmugam MP;Chaitanya V;Ramesh A;Ramanjulu R;Shanmugam MP;Chaitanya V;
{Journal}: Indian J Ophthalmol
{Volume}: 70
{Issue}: 2
{Year}: Feb 2022
{Factor}: 2.969
{DOI}: 10.4103/ijo.IJO_1726_21
{Abstract}: Sub-macular hemorrhage poses a potential threat to vision if left untreated. The preferred surgical technique to clear sub-macular hemorrhage includes vitrectomy followed by retinotomy using a 41G needle with subsequent injection of recombinant tissue plasminogen activator (r-tPA) followed by air/SF6 injection into the sub-retinal space. A malleable nature, increased resistance, and the cost of the 41G needle limit its use. We evaluated the safety and efficacy of a 26G needle for retinotomy as a supplement for the 41G needle in a series of six subjects with sub-macular hemorrhage. A slight modification in the procedure was done by injecting air into the sub-retinal space prior to the r-tPA injection. We found that our technique of using the 26G needle for retinotomy is safe and effective due to its stable nature and self-sealing properties. An air injection prior to r-tPA allows for increased bioavailability of the drug by preventing efflux due to its tamponading effect.