{Reference Type}: Case Reports
{Title}: Intensified Hyposensitization Is an Effective Treatment of Postorgasmic Illness Syndrome (POIS).
{Author}: Wrotynska-Barczynska J;Swat E;Berger A;Pawelczyk L;Jedrzejczak P;
{Journal}: Sex Med
{Volume}: 10
{Issue}: 2
{Year}: Apr 2022
{Factor}: 2.523
{DOI}: 10.1016/j.esxm.2021.100474
{Abstract}: <B>BACKGROUND: </B>Postorgasmic illness syndrome (POIS) is an extremely rare urogenital disease which significantly and negatively impacts the functioning and sexual activity.<BR><B>OBJECTIVE: </B>A 34-year-old male presented with POIS symptoms and confirmed the allergic component of the POIS. Intensified immunotherapy with autologous semen was recommended.<BR><B>METHODS: </B>The treatment lasted 14 months and included 20 visits. Modified and intensified subcutaneous immunotherapy in both forearms significantly shortened the therapy and improved the outcome, with high-tolerance and no adverse effects or hyperactive responses.<BR><B>METHODS: </B>Improvement in POIS symptoms through the use of intensified immunotherapy with autologous semen.<BR><B>RESULTS: </B>The improvement was significant enough to allow for higher sexual activity, and gradual resumption of private and professional activity.<BR><B>CONCLUSIONS: </B>Intensified immunotherapy with autologous semen seems an effective and safe option for treating patients with suspected immune-allergenic POIS. To the best of our knowledge, this has been the first such intensive and effective allergen-specific immunotherapy of POIS. Wrotynska-Barczynska J, Swat. Swat E, Berger A, et al. Intensified Hyposensitization Is an Effective Treatment of Postorgasmic Illness Syndrome (POIS). Sex Med 2022;10:100474.