{Reference Type}: Case Reports
{Title}: Fetal intracranial hemorrhage and maternal vitamin K deficiency induced by total parenteral nutrition: A case report.
{Author}: Lee S;Kim HM;Kang J;Seong WJ;Kim MJ;
{Journal}: Medicine (Baltimore)
{Volume}: 101
{Issue}: 1
{Year}: Jan 2022 7
{Factor}: 1.817
{DOI}: 10.1097/MD.0000000000028434
{Abstract}: <B>BACKGROUND: </B>Fetal brain hemorrhage is rare. It is caused mainly by maternal trauma or fetal coagulation disorder, but in some cases, vitamin K deficiency may be the cause.<BR><B>METHODS: </B>We describe the case of a pregnant woman with bowel obstruction who was susceptible to vitamin K deficiency due to oral diet restriction, decreased intestinal absorption, and limited intravenous vitamin K supplementation.<BR><B>METHODS: </B>After 18 days of intermittent total parenteral nutrition, acute onset of severe fetal brain hemorrhage developed.<BR><B>METHODS: </B>After acute onset of fetal brain hemorrhage, the patient underwent an emergency cesarean section at 25 + 3 weeks of gestation due to fetal non-reassuring fetal monitoring.<BR><B>RESULTS: </B>The Apgar score at birth was 0/0, and despite cardiopulmonary resuscitation, neonatal death was confirmed. After the baby was delivered, we checked the maternal upper abdominal cavity and found a massive adhesion in the small bowel to the abdominal wall near the liver and stomach with an adhesion band. The adhesion band, presumably a complication of previous hepatobiliary surgery, appeared to have caused small bowel obstruction. Adhesiolysis between the small bowel and abdominal wall was performed.<BR><B>CONCLUSIONS: </B>This case demonstrates that even relatively short-term total parenteral nutrition can cause severe fetal brain hemorrhage. Vitamin K supplementation is required for mothers who are expected to be vitamin K deficient, especially if they are on total parenteral nutrition for more than 3 weeks.