{Reference Type}: Review
{Title}: Neurosyphilis in the Northern Territory of Australia: a clinical guideline.
{Author}: Birrell JM;Lowe M;Gunathilake M;Krause VL;
{Journal}: Intern Med J
{Volume}: 53
{Issue}: 5
{Year}: 05 2023 9
{Factor}: 2.611
{DOI}: 10.1111/imj.15691
{Abstract}: The Northern Territory (NT) of Australia is currently experiencing a syphilis epidemic. Neurosyphilis is commonly considered in the differential diagnosis for patients presenting with neurologic conditions such as dementia and stroke in the NT.<BR>To explore the local epidemiologic, diagnostic and treatment complexities of neurosyphilis in the NT and produce a guideline for clinical practice.<BR>A database search was undertaken and local and global neurosyphilis guidelines were analysed. A guideline was created based on findings of the critical review and consultation with local multidisciplinary experts.<BR>Neurosyphilis is frequently encountered in the NT but studies suggest it is often undertreated. Dementia is the most common clinical presentation locally. Establishing a diagnosis of neurosyphilis is complex and requires stepwise evaluation of clinical, laboratory and radiological findings.<BR>A clinical guideline and algorithm have been developed for the diagnosis and management of patients with neurosyphilis.