{Reference Type}: Case Reports {Title}: Erythrodysesthesia: An Unusual Complication With Trastuzumab Monotherapy. {Author}: Fontenot AL;Furr WJ;Husan A;Khan MW;Fontenot AL;Furr WJ;Husan A;Khan MW; {Journal}: Cureus {Volume}: 13 {Issue}: 11 {Year}: Nov 2021 暂无{DOI}: 10.7759/cureus.20060 {Abstract}: Palmar-plantar erythrodysesthesia (PPE), more commonly known as hand-foot syndrome, is a dermatologic complication following chemotherapy with selective agents. In this article, we present the case of a young lady with stage III breast cancer who developed palmar-plantar erythrodysesthesia following treatment with Herceptin (trastuzumab), an unusual complication of this particular drug. From our review of literature, this is the second known occurrence of PPE secondary to trastuzumab monotherapy.