{Reference Type}: Journal Article
{Title}: Outcome after treatment for sebaceous carcinoma: A multicenter study.
{Author}: In 't Veld EH;Keizer R;Post N;Versteeg J;Verdijk R;Naus N;Relyveld G;Crijns M;Smith M;Grünhagen D;Wakkee M;Paridaens D;Zavrakidis I;Mooyaart A;van Akkooi A;Strauss D;Verhoef C;Wouters M;Hayes A;van Houdt W;
{Journal}: J Surg Oncol
{Volume}: 125
{Issue}: 4
{Year}: Mar 2022
{Factor}: 2.885
{DOI}: 10.1002/jso.26774
{Abstract}: <B>BACKGROUND: </B>Sebaceous carcinoma (SC) is a rare malignant tumour whereby, comprehensive long-term data are scarce. This study aimed to assess the outcome of patients treated with resection for SC.<BR><B>METHODS: </B>Patients treated at four tertiary centres were included. Cumulative incidence curves were calculated for recurrences.<BR><B>RESULTS: </B>A total of 100 patients (57 males, 57%) were included with 103 SCs. The median age was 72 (range, 15-95) years with a median follow-up of 52 (interquartile range [IQR], 24-93) months. Most SCs were located (peri)ocular (49.5%). Of all SCs, 17 locally recurred (16.5%) with a median time to recurrence of 19 (IQR, 8-29) months. The cumulative incidence probability for recurrence was statistically higher for (peri)ocular tumours (p = 0.005), and for positive resection margins (p = 0.001). Two patients presented with lymph node metastases and additional seven patients (8.7%) developed lymph node metastases during follow-up with a median time to metastases of 8 (IQR, 0.5-28) months. Three patients had concurrent in-transit metastases and one patient also developed liver and bone metastases during follow-up.<BR><B>CONCLUSIONS: </B>SC is a rare, yet locally aggressive tumour. Positive resection margins and (peri)ocular SCs are more frequently associated with local recurrence. SC infrequently presents with locoregional or distant metastases.