{Reference Type}: Journal Article
{Title}: The Association of the Lymphocyte-to-C-Reactive-Protein Ratio With Gastric Cancer Patients Who Receive Curative Treatment.
{Author}: Aoyama T;Nakazano M;Nagasawa S;Hara K;Komori K;Tamagawa H;Maezawa Y;Segami K;Kano K;Ogata T;Yukawa N;Rino Y;Oshima T;
{Journal}: In Vivo
{Volume}: 36
{Issue}: 1
{Year}: Jan-Feb 2022
{Factor}: 2.406
{DOI}: 10.21873/invivo.12728
{Abstract}: <B>OBJECTIVE: </B>We investigated the association of the preoperative lymphocyte-to-C-reactive-protein ratio (LCR) with gastric cancer survival and recurrence after curative treatment.<BR><B>METHODS: </B>This study included 480 patients who underwent curative surgery followed by adjuvant treatment for gastric cancer between 2013 and 2017. The prognostic factors for overall survival (OS) and recurrence-free survival (RFS) were identified.<BR><B>RESULTS: </B>A LCR of 7,000 was regarded as the optimal critical point of classification, considering the 1-, 3- and 5-year survival rates. The OS rates at 3 and 5 years after surgery were 84.4% and 73.9% in the low-LCR group, respectively, and 92.4% and 87.0% in the high-LCR group, respectively, and were statistically significantly different. The RFS rates at 3 and 5 years after surgery were 78.8% and 68.7% in the low-LCR group, respectively, and 89.3% and 86.6% in the high-LCR group, respectively, with a statistically significant difference. A multivariate analysis showed that the LCR was a significant independent prognostic factor for both OS and RFS.<BR><B>CONCLUSIONS: </B>The LCR was a significant prognostic factor for survival in patients who underwent curative treatment for gastric cancer.