{Reference Type}: Case Reports {Title}: Squamous Cell Papilloma of the Oesophagus: A Human Papilloma Virus Lesion. {Author}: Aladham Y;Ahmed O;Laycock J;Aladham Y;Ahmed O;Laycock J; {Journal}: Cureus {Volume}: 13 {Issue}: 11 {Year}: Nov 2021 暂无{DOI}: 10.7759/cureus.19903 {Abstract}: Oesophageal squamous cell papilloma is a very rare entity with a limited number of reports in the literature. The exact aetiology is uncertain, and it commonly overlaps with gastro-oesophageal reflux. Human papilloma virus (HPV) is deemed responsible for some cases. Although incidental discovery during upper gastrointestinal endoscopy for other reasons is the commonest presentation, symptomatic cases do occur. Endoscopic excision is the standard treatment. We report a case of HPV-positive squamous papilloma of the upper oesophagus, presenting with lateralising throat pain and diagnosed with office transnasal oesophagoscopy. We also discuss features of HPV-positive oesophageal squamous papilloma and the role of transnasal oesophagoscopy as a recent diagnostic modality of increasing popularity.