{Reference Type}: Journal Article {Title}: Highlighting the advantages and benefits of cementless total knee arthroplasty (Review). {Author}: Uivaraseanu B;Vesa CM;Tit DM;Maghiar O;Maghiar TA;Hozan C;Nechifor AC;Behl T;Andronie-Cioara FL;Patrascu JM;Bungau S; {Journal}: Exp Ther Med {Volume}: 23 {Issue}: 1 {Year}: Jan 2022 {Factor}: 2.751 {DOI}: 10.3892/etm.2021.10980 {Abstract}: In the field of orthopedic surgery, cemented total knee arthroplasty (TKA) is considered to be one of the gold standards. However, there are categories of patients (i.e., obese and morbidly obese patients, younger than 65 years old) among whom cemented TKA has however a high failure rate. Moreover, the frequency of using uncemented TKA is increasing due to the potential benefits of long-term biological fixation, being an innovative field that addresses a new generation orthopedic surgical treatment which is more suitable for young patients who have good bone quality (good to very good, in terms of density). The survival rates and functional results of the latest generation of cementless TKAs may be similar to functional results and survival rates of cemented prosthesis. In conclusion, this review-type article can be considered a powerful database, extremely informative, dense, and focused on the topic mentioned above, in the interest of all medical professionals and all interested individuals.