{Reference Type}: Journal Article {Title}: Application of Programmable Tetrahedral Framework Nucleic Acid-Based Nanomaterials in Neurological Disorders: Progress and Prospects. {Author}: Chen X;Xie Y;Liu Z;Lin Y;Chen X;Xie Y;Liu Z;Lin Y; {Journal}: Front Bioeng Biotechnol {Volume}: 9 {Issue}: 0 {Year}: 2021 {Factor}: 6.064 {DOI}: 10.3389/fbioe.2021.782237 {Abstract}: Tetrahedral framework nucleic acid (tFNA), a special DNA nanodevice, is widely applied in diverse biomedical fields. Due to its high programmability, biocompatibility, tissue permeability as well as its capacity for cell proliferation and differentiation, tFNA presents a powerful tool that could overcome potential barriers in the treatment of neurological disorders. This review evaluates recent studies on the use and progress of tFNA-based nanomaterials in neurological disorders.