{Reference Type}: Journal Article {Title}: Surgical Treatment of "Large Uterine Masses" in Pregnancy: A Single-Center Experience. {Author}: Cavaliere AF;Vidiri A;Gueli Alletti S;Fagotti A;La Milia MC;Perossini S;Restaino S;Vizzielli G;Lanzone A;Scambia G; {Journal}: Int J Environ Res Public Health {Volume}: 18 {Issue}: 22 {Year}: 11 2021 19 {Factor}: 4.614 {DOI}: 10.3390/ijerph182212139 {Abstract}: Uterine myomas or uterine fibroids are the most common benign uterine masses affecting women. The management of large myoma during pregnancy is challenging, and surgical treatment is a possible option. We report nine cases of pregnant women affected by uterine masses larger than 10 cm, who underwent surgical treatment during the second trimester of pregnancy. In all cases, the masses were preconceptionally unknown and diagnosed during the first trimester. In eight cases, no maternal and fetal complications arose during or after surgical treatment and delivery occurred at full term of pregnancy. In one case, spontaneous abortion was recorded. In all cases, histologic diagnosis demonstrated the benign nature. Women affected by large uterine masses diagnosed for the first time in pregnancy could be taken into consideration for surgical treatment in a referral center during the second trimester.