{Reference Type}: Journal Article
{Title}: Successful Treatment of Nephrotic Syndrome due to Collapsing Focal Segmental Glomerulosclerosis Accompanied by Acute Interstitial Nephritis: A Case Report.
{Author}: Shima H;Doi T;Okamoto T;Higashiguchi Y;Harada M;Inoue T;Tashiro M;Wariishi S;Takamatsu N;Kawahara K;Okada K;Minakuchi J;
{Journal}: Intern Med
{Volume}: 0
{Issue}: 0
{Year}: Nov 2021 20
{Factor}: 1.282
{DOI}: 10.2169/internalmedicine.8258-21
{Abstract}: A 39-year-old woman was hospitalized for nephrotic syndrome. Laboratory test results showed increased serum creatinine levels and urinary excretions of beta-2-microglobulin, and N-acetyl-beta-D-glucosaminidase. A renal biopsy revealed collapsing focal segmental glomerulosclerosis (FSGS) and acute interstitial nephritis. Despite treatment with pulse steroid followed by oral high-dose glucocorticoids and cyclosporines, heavy proteinuria persisted. After low-density lipoprotein apheresis (LDL-A) therapy was initiated, her proteinuria gradually decreased, leading to complete remission. A repeat renal biopsy after treatment revealed no collapsing glomeruli. Immediate LDL-A should be performed to treat cases of collapsing FSGS poorly responding to other treatments.