{Reference Type}: Journal Article
{Title}: 2020 WHO Classification of Female Genital Tumors.
{Author}: Höhn AK;Brambs CE;Hiller GGR;May D;Schmoeckel E;Horn LC;
{Journal}: Geburtshilfe Frauenheilkd
{Volume}: 81
{Issue}: 10
{Year}: Oct 2021
{Factor}: 2.754
{DOI}: 10.1055/a-1545-4279
{Abstract}: The 2020 WHO classification is focused on the distinction between HPV-associated and HPV-independent squamous cell carcinoma of the lower female genital organs. Differentiating according to HPV association does not replace the process of grading; however, the WHO classification does not recommend any specific grading system. VIN are also differentiated according to whether they are HPV(p16)-associated. HPV-independent adenocarcinoma (AC) of the cervix uteri has an unfavorable prognosis. Immunohistochemical p16 expression is considered to be a surrogate marker for HPV association. HPV-associated AC of the cervix uteri is determined using the prognostically relevant Silva pattern.