{Reference Type}: Journal Article
{Title}: Anti-interleukin 5 therapies failure criteria in severe asthma: a Delphi-consensus study.
{Author}: Mattei L;Suehs CM;Alagha K;Bourdin A;Brousse C;Charriot J;Devouassoux G;Fry S;Guilleminault L;Gouitaa M;Taille C;Chanez P;Pahus L;
{Journal}: Ther Adv Respir Dis
{Volume}: 15
{Issue}: 0
{Year}: Jan-Dec 2021
{Factor}: 5.158
{DOI}: 10.1177/17534666211049735
{Abstract}: <B>UNASSIGNED: </B>Current practices for assessing response to anti-interleukin 5/R treatment in severe asthma patients are heterogeneous. The objective of this study was to achieve an expert consensus defining failure criteria for anti-interleukin 5/R treatment in severe asthma patients.<BR><B>UNASSIGNED: </B>Experts were invited to a 5-round Delphi exercise if they were pulmonologists managing ⩾30 patients at a nationally recognized severe asthma expert centre. Following two rounds of statement-generating brainstorming, the expert panel ranked each statement according to a 5-point Likert-type scale during three additional rounds. Positive consensus was considered achieved when ⩾80% of experts agreed with a statement with >50% strong agreement and <15% disagreement.<BR><B>UNASSIGNED: </B>Twenty experts participated in the study. All experts agreed that predefined treatment goals defining effectiveness should be personalized during shared decision making via a patient contract. Treatment failure was defined as (1) absence of a reduction in exacerbation rates by ⩾25% or (2) absence of a reduction in oral corticosteroid therapy by ⩾25% of the initial dosage or (3) occurrence of emergency room visits or hospitalizations after 6 months of treatment. Treatment failure should result in discontinuation. For partial responders, treatment discontinuation was not recommended unless an alternative from another therapeutic class exists and should be discussed in a multidisciplinary consultation.<BR><B>UNASSIGNED: </B>The present study provides objective criteria for anti IL5 or IL5R failure in severe asthma and suggests consensus based guidelines for prescription, evaluation and discontinuation decision-making.