{Reference Type}: Journal Article
{Title}: A preliminary study investigating the detection of lymphovascular invasion in germ cell tumors of the testis with double staining for OCT4/CD34.
{Author}: Ricci C;Franceschini T;Giunchi F;Borsato M;Mollica V;Massari F;Fiorentino M;
{Journal}: Pathol Res Pract
{Volume}: 227
{Issue}: 0
{Year}: Nov 2021
{Factor}: 3.309
{DOI}: 10.1016/j.prp.2021.153637
{Abstract}: Lymphovascular invasion (LVI) is a relevant prognostic factor in germ cell tumors of the testis (GCTT) and it has been included in the AJCC staging system. Nevertheless, its histological assessment is challenging, with low/moderate interobserver agreement also among expert uropathologists. Few studies focused on the potential role of immunohistochemistry to solve this critical issue; as result, in current guidelines there is no indication for additional staining to detect this histological feature. In the present study, we investigated the detection of LVI invasion in a small cohort of GCTT with double staining for OCT4/CD34. Although our results need to be validated in larger case series with follow-up data, they suggest as OCT4/CD34 could be a useful tool for the histological assessment of these tumors, helping to identify some histological mimickers of LVI and modifying the pT/stage in a significant percentage of patients.