{Reference Type}: Journal Article
{Title}: Perfusion measured by laser speckle contrast imaging as a predictor for expansion of psoriasis lesions.
{Author}: Schaap MJ;Chizari A;Knop T;Groenewoud HMM;van Erp PEJ;de Jong EMGJ;Steenbergen W;Seyger MMB;
{Journal}: Skin Res Technol
{Volume}: 0
{Issue}: 0
{Year}: Oct 2021 7
{Factor}: 2.24
{DOI}: 10.1111/srt.13098
{Abstract}: <B>BACKGROUND: </B>Skin microvasculature changes are crucial in psoriasis development and correlate with perfusion. The noninvasive Handheld Perfusion Imager (HAPI) examines microvascular skin perfusion in large body areas using laser speckle contrast imaging (LSCI).<BR><B>OBJECTIVE: </B>To (i) assess whether increased perilesional perfusion and perfusion inhomogeneity are predictors for expansion of psoriasis lesions and (ii) assess feasibility of the HAPI system in a mounted modality.<BR><B>METHODS: </B>In this interventional pilot study in adults with unstable plaque psoriasis, HAPI measurements and color photographs were performed for lesions present on one body region at week 0, 2, 4, 6 and 8. The presence of increased perilesional perfusion and perfusion inhomogeneity was determined. Clinical outcome was categorized as increased, stable or decreased lesion surface between visits. Patient feedback was collected on a 10-point scale.<BR><B>RESULTS: </B>In total, 110 lesions with a median follow-up of 6 (IQR 6.0) weeks were assessed in 6 patients with unstable plaque psoriasis. Perfusion data was matched to 281 clinical outcomes after two weeks. A mixed multinomial logistic regression model revealed a predictive value of perilesional increased perfusion (OR 9.90; p < 0.001) and perfusion inhomogeneity (OR 2.39; p = 0.027) on lesion expansion after two weeks compared to lesion stability. HAPI measurements were considered fast, patient-friendly and important by patients.<BR><B>CONCLUSIONS: </B>Visualization of increased perilesional perfusion and perfusion inhomogeneity by noninvasive whole field LSCI holds potential for prediction of psoriatic lesion expansion. Furthermore, the HAPI is a feasible and patient-friendly tool.