{Reference Type}: Journal Article
{Title}: Significant Association of CCND1 Genotypes With Susceptibility to Childhood Acute Lymphoblastic Leukemia.
{Author}: Hsu PC;Pei JS;Chen CC;Chang WS;Chin YT;Huang TL;Yang JS;Wang YC;Chen JC;Hsu YN;Tsai CW;Bau DT;
{Journal}: Anticancer Res
{Volume}: 41
{Issue}: 10
{Year}: Oct 2021
{Factor}: 2.435
{DOI}: 10.21873/anticanres.15295
{Abstract}: <B>OBJECTIVE: </B>This study investigated whether genetic variations in cyclin D1 (CCND1) are associated with susceptibility to childhood acute lymphoblastic leukemia (ALL).<BR><B>METHODS: </B>A total of 266 childhood ALL cases and 266 healthy controls were genotyped for CCND1 rs9344 and rs678653.<BR><B>RESULTS: </B>There was a significant difference in the genotypic distribution of rs9344 between childhood ALL patients and healthy controls (p=0.0077). Compared to the AA genotype, AG and GG genotypes were associated with significantly decreased risks of childhood ALL with odds ratio (OR) of 0.65 [95% confidence interval (CI)=0.44-0.94, p=0.0234] and 0.45 (95%CI=0.26-0.78, p=0.0040), respectively. Supporting this, allelic frequency distributions between childhood ALL patients and controls was significantly different (OR=0.68, 95%CI=0.53-0.88, p=0.0025). There was no significant difference in the genotypic and allelic distributions of rs678653 between cases and controls.<BR><B>CONCLUSIONS: </B>CCND1 rs9344, but not rs678653, may serve as a predictive marker of susceptibility for childhood ALL.