{Reference Type}: Journal Article
{Title}: Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain.
{Author}: Segura A;Ballester P;Ajo R;Inda MD;Urbano A;Muriel J;Ochando I;Margarit C;Martinez E;Peiró AM;
{Journal}: Gene
{Volume}: 721
{Issue}: 0
{Year}: 2019
{Factor}: 3.913
{DOI}: 10.1016/j.gene.2019.100005
{Abstract}: <B>OBJECTIVE: </B>To investigate whether endothelial nitric oxide synthase (eNOS) T786C, 4VNTR and G894 T gene polymorphisms could mediate in andrological treatment response in Spaniards.<BR><B>UNASSIGNED: </B>The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n = 105) recruited at the Pain Unit. eNOS polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses were carried out using R-3.2.4 software.<BR><B>RESULTS: </B>A total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indicated that age, opioid daily dose and carriage of T786C-C allele influenced the risk and ED severity in Spaniard chronic pain patients.<BR><B>CONCLUSIONS: </B>T786C polymorphism at eNOS locus appeared to be a major contributor in the variable erectile function iPDE5/testosterone response in Spaniards.