{Reference Type}: Journal Article
{Title}: When Benign Becomes Cancer: Malignant Degeneration of Chronic Inflammation.
{Author}: Conlon C;Pupa L;Reece EM;Chu CK;Yu JZ;Vorstenbosch J;Winocour S;
{Journal}: Semin Plast Surg
{Volume}: 35
{Issue}: 3
{Year}: Aug 2021
{Factor}: 2.195
{DOI}: 10.1055/s-0041-1731462
{Abstract}: Chronic inflammation, long implicated in the genesis of malignancy, is now understood to underlie an estimated 25% of all cancers. The most pertinent malignancies, to the plastic surgeon, associated with the degeneration of chronic inflammation include Marjolin's ulcer, breast implant-associated large cell lymphoma, radiation-induced sarcoma, and Kaposi's sarcoma. The cellular and genetic damage incurred by a prolonged inflammatory reaction is controlled by an increasingly understood cytokinetic system. Advances in understanding the chronic inflammatory cascade have yielded new therapeutics and therapeutic targets.