{Reference Type}: Journal Article
{Title}: Construction of a survival prediction model for high-and low -grade UTUC after tumor resection based on "SEER database": a multicenter study.
{Author}: Wang M;Ren X;Wang G;Sun X;Tang S;Zhang B;Xing X;Zhang W;Gao G;Du J;Zhang S;Liu L;Zheng X;Zhang Z;Sun C;
{Journal}: BMC Cancer
{Volume}: 21
{Issue}: 1
{Year}: Sep 2021 7
{Factor}: 4.638
{DOI}: 10.1186/s12885-021-08742-3
{Abstract}: BACKGROUND: There are differences in survival between high-and low-grade Upper Tract Urothelial Carcinoma (UTUC). Our study aimed to develop a nomogram to predict overall survival (OS) of patients with high- and low-grade UTUC after tumor resection, and to explore the difference between high- and low-grade patients.
METHODS: Patients confirmed to have UTUC between 2004 and 2015 were selected from the Surveillance, Epidemiology and End Results (SEER) database. The UTUCs were identified and classified as high- and low-grade, and 1-, 3- and 5-year nomograms were established. The nomogram was then validated using the Chinese multicenter dataset (patients diagnosed in Shandong, China between January 2010 and October 2020).
RESULTS: In the high-grade UTUC patients, nine important factors related to survival after tumor resection were identified to construct nomogram. The C index of training dataset was 0.740 (95% confidence interval [CI]: 0.727-0.754), showing good calibration. The C index of internal validation dataset was 0.729(95% CI:0.707-0.750). On the other hand, Two independent predictors were identified to construct nomogram of low-grade UTUC. The C index was 0.714 (95% CI: 0.671-0.758) for the training set,0.731(95% CI:0.670-0.791) for the internal validation dataset. Encouragingly, the nomogram was clinically useful and had a good discriminative ability to identify patients at high risk.
CONCLUSIONS: We constructed a nomogram and a corresponding risk classification system predicting the OS of patients with an initial diagnosis of high-and low-grade UTUC.