{Reference Type}: Journal Article
{Title}: Shining light on location-biased cAMP signaling.
{Author}: Vilardaga JP;Sutkeviciute I;Peña KA;
{Journal}: J Biol Chem
{Volume}: 297
{Issue}: 3
{Year}: 09 2021
暂无{DOI}: 10.1016/j.jbc.2021.101118
{Abstract}: cAMP is the indispensable second messenger regulating cell metabolism and function in response to extracellular hormones and neurotransmitters. cAMP is produced via the activation of G protein-coupled receptors located at both the cell surface and inside the cell. Recently, Tsvetanova et al. explored cAMP generation in distinct locations and the impact on respective cell functions. Using a phospho-proteomic analysis, they provide insight into the unique role of localized cAMP production in cellular phospho-responses.