{Reference Type}: Journal Article
{Title}: Eremophilane sesquiterpenoids from the whole plant of Parasenecio albus with immunosuppressive activity.
{Author}: Zhou M;Duan F;Gao Y;Peng X;Meng X;Ruan H;
{Journal}: Bioorg Chem
{Volume}: 115
{Issue}: 0
{Year}: 10 2021
{Factor}: 5.307
{DOI}: 10.1016/j.bioorg.2021.105247
{Abstract}: Fifteen new highly oxygenated eremophilane sesquiterpenoids, parasubolides A-O (1-15), were obtained from the whole plant of Parasenecio albus. The structures of 1-15 were elucidated based on the interpretation of NMR and HRESIMS data, along with experimental electronic circular dichroism (ECD) and single-crystal X-ray diffraction analysis. Compounds 1-6, and 9-14 represent the first class of 1,2,10-trioxygenated eremophilane lactones. Selected isolates were evaluated for their immunosuppressive activities. Compounds 4, 5, and 12 exhibited moderate inhibition against LPS-induced B-cell proliferation with IC50 values of 23.1, 33.8, and 26.6 μM, respectively.