{Reference Type}: Case Reports
{Title}: Case Report: A Re-Positive Case of SARS-CoV-2 Associated With Glaucoma.
{Author}: Zhou X;Zhou YN;Ali A;Liang C;Ye Z;Chen X;Zhang Q;Deng L;Sun X;Zhang Q;Luo J;Li W;Zhou K;Cao S;Zhang X;Li XD;Zhang XE;Cui Z;Men D;
{Journal}: Front Immunol
{Volume}: 12
{Issue}: 0
{Year}: 2021
{Factor}: 8.786
{DOI}: 10.3389/fimmu.2021.701295
{Abstract}: The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has already become a global threat to the human population. Infection with SARS-CoV-2 leads to a wide spectrum of clinical manifestations. Ocular abnormalities have been reported in association with COVID-19, but the nature of the impairments was not specified. Here, we report a case of a female patient diagnosed with glaucoma on re-hospitalization for ocular complications two months after being discharged from the hospital upon recovery from COVID-19. Meanwhile, the patient was found re-positive for SARS-CoV-2 in the upper respiratory tract. The infection was also diagnosed in the aqueous humor through immunostaining with antibodies against the N protein and S protein of SARS-CoV-2. Considering the eye is an immune-privileged site, we speculate that SARS-CoV-2 survived in the eye and resulted in the patient testing re-positive for SARS-CoV-2.