{Reference Type}: Journal Article
{Title}: Deficiency of peroxisome proliferator-activated receptor α attenuates apoptosis and promotes migration of vascular smooth muscle cells.
{Author}: Duan Y;Qi D;Liu Y;Song Y;Wang X;Jiao S;Li H;Gonzalez FJ;Qi Y;Xu Q;Du J;Qu A;
{Journal}: Biochem Biophys Rep
{Volume}: 27
{Issue}: 0
{Year}: Sep 2021
暂无{DOI}: 10.1016/j.bbrep.2021.101091
{Abstract}: Peroxisome proliferator-activated receptor (PPAR) α is widely expressed in the vasculature and has pleiotropic and lipid-lowering independent effects, but its role in the growth and function of vascular smooth muscle cells (VSMCs) during vascular pathophysiology is still unclear. Herein, VSMC-specific PPARα-deficient mice (Ppara ΔSMC) were generated by Cre-LoxP site-specific recombinase technology and VSMCs were isolated from mice aorta. PPARα deficiency attenuated VSMC apoptosis induced by angiotensin (Ang) II and hydrogen peroxide, and increased the migration of Ang II-challenged cells.