{Reference Type}: Journal Article
{Title}: Systemic oxidative stress biomarkers in patients with vitreomacular traction syndrome.
{Author}: Kilic D;Kocer D;Sırakaya E;Küçük B;Vural E;Guven S;Duru N;
{Journal}: Int Ophthalmol
{Volume}: 41
{Issue}: 11
{Year}: Nov 2021
{Factor}: 2.029
{DOI}: 10.1007/s10792-021-01949-0
{Abstract}: <B>OBJECTIVE: </B>To evaluate whether the systemic oxidative stress biomarkers increased in patients with vitreomacular traction syndrome (VMT).<BR><B>METHODS: </B>This study compared 25 patients diagnosed with VMT with 20 healthy controls. As a biomarker of systemic oxidative stress, malondialdehyde (MDA) was measured. Total oxidant status (TOS) and total antioxidant status (TAS) were measured to evaluate the systemic oxidant status.<BR><B>RESULTS: </B>Serum MDA values were significantly higher among the patients (p < 0.001). The ideal cut-off value for MDA was determined to be 22.1 µmol/L, with 80% sensitivity and 75% specificity. The between-group differences were not statistically significant for TOS or TAS (p = 0.326 and p = 0.698, respectively).<BR><B>CONCLUSIONS: </B>Increased MDA levels suggest that systemic oxidative stress may play a role in VMT.