{Reference Type}: Journal Article
{Title}: Prognostic Factors and Outcomes of De Novo Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta-analysis.
{Author}: Nguyen ES;Risbud A;Birkenbeuel JL;Murphy LS;Goshtasbi K;Pang JC;Abiri A;Lehrich BM;Haidar YM;Tjoa T;Kuan EC;
{Journal}: Otolaryngol Head Neck Surg
{Volume}: 0
{Issue}: 0
{Year}: Jul 2021 13
{Factor}: 5.591
{DOI}: 10.1177/01945998211021023
{Abstract}: <B>OBJECTIVE: </B>To review overall survival (OS), recurrence patterns, and prognostic factors of de novo sinonasal squamous cell carcinoma (DN-SCC).<BR><B>METHODS: </B>PubMed, Scopus, OVID Medline, and Cochrane databases from 2006 to December 23, 2020.<BR><B>METHODS: </B>The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Articles were required to report either recurrence patterns or survival outcomes of adults with DN-SCC. Case reports, books, reviews, meta-analyses, and database studies were all excluded.<BR><B>RESULTS: </B>Forty-one studies reported on survival or recurrence outcomes. The aggregate 5-year OS was 54.5% (range, 18%-75%) from 35 studies (n = 1903). Patients undergoing open surgery were more likely to receive radiation therapy and present at an advanced stage compared to those receiving endoscopic surgery (all P < .001). Advanced T stage, presence of cervical nodal metastases, maxillary sinus primary site, and negative human papillomavirus (HPV) status were all correlated with significantly worse 5-year OS. Direct meta-analysis of 8 studies demonstrated patients with surgery were more likely to be alive at 5 years compared to those who did not receive surgery (odds ratio, 2.26; 95% CI, 1.48-3.47; P < .001). Recurrence was reported in 628 of 1471 patients from 26 studies (42.7%) with an aggregate 5-year locoregional control rate of 67.1% (range, 50.4%-93.3%).<BR><B>CONCLUSIONS: </B>This systematic review and meta-analysis suggests that the 5-year OS rate for DN-SCC may approach 54.5% and recurrence rate approaches 42.7%. In addition, various tumor characteristics including advanced T stage, positive nodal status, maxillary sinus origin, and negative HPV status are all associated with decreased survival.