{Reference Type}: Journal Article
{Title}: The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis.
{Author}: Teng L;Feng YC;Guo ST;Wang PL;Qi TF;Yue YM;Wang SX;Zhang SN;Tang CX;La T;Zhang YY;Zhao XH;Gao JN;Wei LY;Zhang D;Wang JY;Shi Y;Liu XY;Li JM;Cao H;Liu T;Thorne RF;Jin L;Shao FM;Zhang XD;
{Journal}: Nat Commun
{Volume}: 12
{Issue}: 1
{Year}: 06 2021 18
{Factor}: 17.694
{DOI}: 10.1038/s41467-021-24099-4
{Abstract}: Genomic amplification of the distal portion of chromosome 3q, which encodes a number of oncogenic proteins, is one of the most frequent chromosomal abnormalities in malignancy. Here we functionally characterise a non-protein product of the 3q region, the long noncoding RNA (lncRNA) PLANE, which is upregulated in diverse cancer types through copy number gain as well as E2F1-mediated transcriptional activation. PLANE forms an RNA-RNA duplex with the nuclear receptor co-repressor 2 (NCOR2) pre-mRNA at intron 45, binds to heterogeneous ribonucleoprotein M (hnRNPM) and facilitates the association of hnRNPM with the intron, thus leading to repression of the alternative splicing (AS) event generating NCOR2-202, a major protein-coding NCOR2 AS variant. This is, at least in part, responsible for PLANE-mediated promotion of cancer cell proliferation and tumorigenicity. These results uncover the function and regulation of PLANE and suggest that PLANE may constitute a therapeutic target in the pan-cancer context.